By Steve Holland, Parisa Hafezi and Alexander Cornwell

WASHINGTON/DUBAI/JERUSALEM (Reuters) -Iranian missiles struck an Israeli hospital on Thursday while Israel hit targets across Iran as President Donald Trump kept the world guessing about whether the U.S. would join Israel in air strikes seeking to destroy Tehran's nuclear facilities.

A week of Israeli air and missile strikes against its major rival has wiped out the top echelon of Iran's military command, damaged its nuclear capabilities and killed hundreds of people, while Iranian retaliatory strikes have killed at least two dozen civilians in Israel.

The worst-ever conflict between the two regional powers has raised fears that it will draw in world powers and further destabilize the Middle East.

Speaking to reporters outside the White House on Wednesday, Trump declined to say if he had made any decision on whether to join Israel's air campaign. "I may do it. I may not do it. I mean, nobody knows what I'm going to do," he said.

Trump in later remarks said Iranian officials wanted to come to Washington for a meeting. "We may do that" he said, adding "it's a little late" for such talks.

Iranian Supreme Leader Ayatollah Ali Khamenei rebuked Trump's earlier call for Iran to surrender in a recorded speech played on television, his first appearance since Friday.

"Any U.S. military intervention will undoubtedly be accompanied by irreparable damage," he said. "The Iranian nation will not surrender."

Iran denies it is seeking nuclear weapons and says its program is for peaceful purposes only. The International Atomic Energy Agency said last week Tehran was in breach of its non-proliferation obligations for the first time in 20 years.

The foreign ministers of Germany, France and Britain plan to hold nuclear talks with their Iranian counterpart on Friday in Geneva to urge Iran to return to the negotiating table, a German diplomatic source told Reuters.

Israel, which is not a party to the international Non-Proliferation Treaty, is the only country in the Middle East believed to have nuclear weapons. Israel does not deny or confirm that.

DRONE ATTACKS

On Thursday morning, several Iranian missiles struck populated areas in Israel, including a hospital in the southern part of the country, according to an Israeli military official.

Trails of missiles and interception efforts were visible in the skies over Tel Aviv, with explosions heard as incoming projectiles were intercepted. Israeli media also reported direct hits in central Israel.

Emergency services said five people had been seriously injured in the attacks and dozens of others hurt in three separate locations. People were still trapped in a building in a south Tel Aviv neighbourhood, they added.

Images showed buildings extensively damaged in Ramat Ghan near Tel Aviv and emergency workers helping residents, including children. Soroka Medical Center in Beersheba, in southern Israel, reported it had sustained damage.

Iran's Revolutionary Guard said it was targeting Israeli military and intelligence headquarters near the hospital.

In Iran, the ISNA news agency reported that an area near the heavy water facility of the Khondab nuclear facility was targeted by Israel.

Earlier, air defences were activated in Tehran, intercepting drones on the outskirts of the capital, the semi-official SNN news agency reported. Iranian news agencies also reported it had arrested 18 "enemy agents" who were building drones for Israeli attacks in the northeastern city of Mashhad.

Some residents of Tehran, a city of 10 million people, jammed highways out of the city on Wednesday.

Arezou, a 31-year-old Tehran resident, told Reuters by phone that she had made it to the nearby resort town of Lavasan.

"My friend’s house in Tehran was attacked and her brother was injured. They are civilians," she said. "Why are we paying the price for the regime’s decision to pursue a nuclear programme?"

CALLS FOR DIPLOMACY

Trump has veered from proposing a swift diplomatic end to the war to suggesting the United States might join it.

A source familiar with internal discussions said Trump and his team were considering options that included joining Israel in strikes against Iranian nuclear installations.

But the prospect of a U.S. strike against Iran has exposed divisions in the coalition of supporters that brought Trump to power, with some of his base urging him not to get the country involved in a new Middle East war.

Senior U.S. Senate Democrats urged Trump to prioritise diplomacy and seek a binding agreement to prevent Iran from attaining nuclear weapons, while expressing concern about his administration's approach.

"We are alarmed by the Trump administration's failure to provide answers to fundamental questions. By law, the president must consult Congress and seek authorization if he is considering taking the country to war," they said in a statement.

"He owes Congress and the American people a strategy for U.S. engagement in the region."

In social media posts on Tuesday, Trump mused about killing Khamenei.

Russian President Vladimir Putin, asked what his reaction would be if Israel did kill Iran's Supreme Leader with the assistance of the United States, said on Thursday: "I do not even want to discuss this possibility. I do not want to."

Putin said all sides should look for ways to end hostilities in a way that ensured both Iran's right to peaceful nuclear power and Israel's right to the unconditional security of the Jewish state.

Since Friday, Iran has fired around 400 missiles at Israel, some 40 of which have pierced air defences, killing 24 people, all of them civilians, according to Israeli authorities.

The Iranian missile salvoes mark the first time in decades of shadow war and proxy conflict that a significant number of projectiles fired from Iran have penetrated defences, killing Israelis in their homes.

Iran has reported at least 224 deaths in Israeli attacks, mostly civilians, but has not updated that toll for days.

U.S.-based Iranian activist news agency HRANA said 639 people had been killed in the Israeli attacks and 1,329 injured as of June 18. Reuters could not independently verify the report.

(Reporting by Reuters; Writing by Lincoln Feast; Editing by Saad Sayeed)

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